Differential Loss of Prolyl Isomerase or Chaperone Activity of Ran-binding Protein 2 (Ranbp2) Unveils Distinct Physiological Roles of Its Cyclophilin Domain in Proteostasis

The immunophilins, cyclophilins, catalyze peptidyl cis-trans prolyl-isomerization (PPIase), a rate-limiting step in protein folding and a conformational switch in protein function. Cyclophilins are also chaperones. Noncatalytic mutations affecting the only cyclophilins with known but distinct physio...

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מידע ביבליוגרפי
Main Authors: Cho, Kyoung-in, Patil, Hemangi, Senda, Eugene, Wang, Jessica, Yi, Haiqing, Qiu, Sunny, Yoon, Dosuk, Yu, Minzhong, Orry, Andrew, Peachey, Neal S., Ferreira, Paulo A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2014
נושאים:
Protein Synthesis and Degradation
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931022/
https://ncbi.nlm.nih.gov/pubmed/24403063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.538215
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