Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2

The Ran-binding protein 2 (Ranbp2/Nup358) is a cytoplasmic and peripheral nucleoporin comprised of 4 Ran-GTP-binding domains (RBDs) that are interspersed among diverse structural domains with multifunctional activities. Our prior studies found that the RBD2 and RBD3 of Ranbp2 control mitochondrial m...

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Detalhes bibliográficos
Publicado no:Small GTPases
Main Authors: Patil, Hemangi, Yoon, Dosuk, Bhowmick, Reshma, Cai, Yunfei, Cho, Kyoung-in, Ferreira, Paulo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380291/
https://ncbi.nlm.nih.gov/pubmed/28877029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2017.1356432
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