Selective Impairment of a Subset of Ran-GTP-binding Domains of Ran-binding Protein 2 (Ranbp2) Suffices to Recapitulate the Degeneration of the Retinal Pigment Epithelium (RPE) Triggered by Ranbp2 Ablation

Retinal pigment epithelium (RPE) degeneration underpins diseases triggered by disparate genetic lesions, noxious insults, or both. The pleiotropic Ranbp2 controls the expression of intrinsic and extrinsic pathological stressors impinging on cellular viability. However, the physiological targets and...

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Autores principales: Patil, Hemangi, Saha, Arjun, Senda, Eugene, Cho, Kyoung-in, Haque, MdEmdadul, Yu, Minzhong, Qiu, Sunny, Yoon, Dosuk, Hao, Ying, Peachey, Neal S., Ferreira, Paulo A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207991/
https://ncbi.nlm.nih.gov/pubmed/25187515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586834
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