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Selective Impairment of a Subset of Ran-GTP-binding Domains of Ran-binding Protein 2 (Ranbp2) Suffices to Recapitulate the Degeneration of the Retinal Pigment Epithelium (RPE) Triggered by Ranbp2 Ablation

Retinal pigment epithelium (RPE) degeneration underpins diseases triggered by disparate genetic lesions, noxious insults, or both. The pleiotropic Ranbp2 controls the expression of intrinsic and extrinsic pathological stressors impinging on cellular viability. However, the physiological targets and...

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Main Authors: Patil, Hemangi, Saha, Arjun, Senda, Eugene, Cho, Kyoung-in, Haque, MdEmdadul, Yu, Minzhong, Qiu, Sunny, Yoon, Dosuk, Hao, Ying, Peachey, Neal S., Ferreira, Paulo A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207991/
https://ncbi.nlm.nih.gov/pubmed/25187515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586834
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