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Preliminary Pharmacological Evaluation of Enantiomeric Morphinans

[Image: see text] A series of levo- and dextromorphinan pairs have been synthesized and evaluated for their affinities to the mu, kappa, and delta opioid receptors, the N-methyl-d-aspartate (NMDA) channel, and sigma 1 and 2 receptors. It was found that levo isomers tended to have higher affinities a...

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Autori principali: Sromek, Anna W., Provencher, Brian A., Russell, Shayla, Chartoff, Elena, Knapp, Brian I., Bidlack, Jean M., Neumeyer, John L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930996/
https://ncbi.nlm.nih.gov/pubmed/24393077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400205z
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