Plasminogen Activator Inhibitor-1 Deficiency Augments Visceral Mesothelial Organization, Intrapleural Coagulation, and Lung Restriction in Mice with Carbon Black/Bleomycin–Induced Pleural Injury

Local derangements of fibrin turnover and plasminogen activator inhibitor (PAI)-1 have been implicated in the pathogenesis of pleural injury. However, their role in the control of pleural organization has been unclear. We found that a C57Bl/6j mouse model of carbon black/bleomycin (CBB) injury demon...

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Hauptverfasser: Tucker, Torry A., Jeffers, Ann, Alvarez, Alexia, Owens, Shuzi, Koenig, Kathleen, Quaid, Brandon, Komissarov, Andrey A., Florova, Galina, Kothari, Hema, Pendurthi, Usha, Mohan Rao, L. Vijaya, Idell, Steven
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2014
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930954/
https://ncbi.nlm.nih.gov/pubmed/24024554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0300OC
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