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Thrombin Down-Regulates Tissue Factor Pathway Inhibitor Expression in a PI3K/Nuclear Factor-κB–Dependent Manner in Human Pleural Mesothelial Cells

Tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the extrinsic coagulation cascade, and its expression is reported to be relatively stable. Various pathophysiologic agents have been shown to influence TFPI activity by regulating its expression or by modifying the protein. It is not...

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Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Jeffers, Ann, Owens, Shuzi, Koenig, Kathleen, Quaid, Brandon, Pendurthi, Usha R., Rao, Vijaya M., Idell, Steven, Tucker, Torry A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491127/
https://ncbi.nlm.nih.gov/pubmed/25303460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0084OC
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