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Compartmental models for apical efflux by P-glycoprotein. Part 2. A theoretical study on transporter kinetic parameters
PURPOSE: The impact of efflux transporters in intracellular concentrations of a drug can be predicted with modeling techniques. In Part 1, several compartmental models were developed and evaluated. The goal of Part 2 was to apply these models to the characterization and interpretation of saturation...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3930629/ https://ncbi.nlm.nih.gov/pubmed/23959852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-1163-8 |
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