Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

The CARMA1/Bcl10/MALT1 (CBM) signalosome mediates antigen receptor-induced NF-κB signaling to regulate multiple lymphocyte functions. While CARMA1 and Bcl10 contain caspase recruitment domains (CARDs), MALT1 is a paracaspase with structural similarity to caspases. Here we show that the reconstituted...

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Bibliografski detalji
Glavni autori: Qiao, Qi, Yang, Chenghua, Zheng, Chao, Fontán, Lorena, David, Liron, Yu, Xiong, Bracken, Clay, Rosen, Monica, Melnick, Ari, Egelman, Edward H., Wu, Hao
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929958/
https://ncbi.nlm.nih.gov/pubmed/24074955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.08.032
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