High-throughput glycosylation analysis of therapeutic immunoglobulin G by capillary gel electrophoresis using a DNA analyzer

The Fc glycosylation of therapeutic antibodies is crucial for their effector functions and their behavior in pharmacokinetics and pharmacodynamics. To monitor the Fc glycosylation in bioprocess development and characterization, high-throughput techniques for glycosylation analysis are needed. Here,...

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Main Authors: Reusch, Dietmar, Haberger, Markus, Kailich, Tobias, Heidenreich, Anna-Katharina, Kampe, Michael, Bulau, Patrick, Wuhrer, Manfred
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929442/
https://ncbi.nlm.nih.gov/pubmed/24135630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26712
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