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Dual-tagged amyloid-β precursor protein reveals distinct transport pathways of its N- and C-terminal fragments

The amyloid-β precursor protein (APP), a type I transmembrane protein genetically associated with Alzheimer's disease, has a complex biology that includes proteolytic processing into potentially toxic fragments, extensive trafficking and multiple, yet poorly-defined functions. We recently propo...

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Detalhes bibliográficos
Main Authors: Villegas, Christine, Muresan, Virgil, Ladescu Muresan, Zoia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929097/
https://ncbi.nlm.nih.gov/pubmed/24203698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt555
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