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The Amyloid-β Precursor Protein Is Phosphorylated via Distinct Pathways during Differentiation, Mitosis, Stress, and Degeneration

Phosphorylation of amyloid-β precursor protein (APP) at Thr(668) is a normal process linked to neurite extension and anterograde transport of vesicular cargo. By contrast, increased phosphorylation of APP is a pathological trait of Alzheimer's disease. APP is overexpressed in Down's syndro...

詳細記述

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書誌詳細
主要な著者: Muresan, Zoia, Muresan, Virgil
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Cell Biology 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995701/
https://ncbi.nlm.nih.gov/pubmed/17634293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-07-0625
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