Coenzyme Q10 Inhibits Glutamate Excitotoxicity and Oxidative Stress–Mediated Mitochondrial Alteration in a Mouse Model of Glaucoma

PURPOSE. To test whether a diet supplemented with coenzyme Q10 (CoQ(10)) ameliorates glutamate excitotoxicity and oxidative stress–mediated retinal ganglion cell (RGC) degeneration by preventing mitochondrial alterations in the retina of glaucomatous DBA/2J mice. METHODS. Preglaucomatous DBA/2J and...

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Main Authors: Lee, Dongwook, Shim, Myoung Sup, Kim, Keun-Young, Noh, You Hyun, Kim, Heemin, Kim, Sang Yeop, Weinreb, Robert N., Ju, Won-Kyu
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929080/
https://ncbi.nlm.nih.gov/pubmed/24458150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12564
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