MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells

Janus kinase (JAK) and Src kinase are the two major tyrosine kinase families upstream of signal transducer and activator of transcription (STAT). Among the seven STAT family proteins, STAT3 is constitutively activated in many diverse cancers. Upon activation, JAK and Src kinases phosphorylate STAT3,...

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Detalhes bibliográficos
Main Authors: Liu, Lucy, Gaboriaud, Nicolas, Vougogianopoulou, Konstantina, Tian, Yan, Wu, Jun, Wen, Wei, Skaltsounis, Leandros, Jove, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928133/
https://ncbi.nlm.nih.gov/pubmed/24100507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.26721
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