6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells

Signal Transducer and Activator of Transcription 3 (STAT3) is persistently activated and contributes to malignant progression in various cancers. Janus kinases (JAKs) phosphorylate STAT3 in response to stimulation with cytokines or growth factors. The STAT3 signaling pathway has been validated as a...

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Detalhes bibliográficos
Main Authors: Liu, Lucy, Nam, Sangkil, Tian, Yan, Yang, Fan, Wu, Jun, Wang, Yan, Scuto, Anna, Polychronopoulos, Panos, Magiatis, Prokopios, Skaltsounis, Leandros, Jove, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107399/
https://ncbi.nlm.nih.gov/pubmed/21610112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3852
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