6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells

Signal Transducer and Activator of Transcription 3 (STAT3) is persistently activated and contributes to malignant progression in various cancers. Janus kinases (JAKs) phosphorylate STAT3 in response to stimulation with cytokines or growth factors. The STAT3 signaling pathway has been validated as a...

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Hlavní autoři: Liu, Lucy, Nam, Sangkil, Tian, Yan, Yang, Fan, Wu, Jun, Wang, Yan, Scuto, Anna, Polychronopoulos, Panos, Magiatis, Prokopios, Skaltsounis, Leandros, Jove, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107399/
https://ncbi.nlm.nih.gov/pubmed/21610112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3852
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