Small Molecule Multi-Targeted Kinase Inhibitor RGB-286638 Triggers P53-Dependent and -Independent Anti-Multiple Myeloma Activity through Inhibition of Transcriptional CDKs

Small molecule multi-targeted CDK inhibitors (CDKIs) are of particular interest due to their potent antitumor activity independent of p53 gene alterations. P53 deletion is associated with a very poor prognosis in multiple myeloma (MM). In this regard, we tested the anti-MM activity of RGB-286638, an...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Cirstea, Diana, Hideshima, Teru, Santo, Loredana, Eda, Homare, Mishima, Yuko, Nemani, Neeharika, Hu, Yiguo, Mimura, Naoya, Cottini, Francesca, Gorgun, Gullu, Ohguchi, Hiroto, Suzuki, Rikio, Loferer, Hannes, Munshi, Nikhil C., Anderson, Kenneth C., Raje, Noopur
التنسيق: Artigo
اللغة:Inglês
منشور في: 2013
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928098/
https://ncbi.nlm.nih.gov/pubmed/23807770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.194
الوسوم: إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة