Small Molecule Multi-Targeted Kinase Inhibitor RGB-286638 Triggers P53-Dependent and -Independent Anti-Multiple Myeloma Activity through Inhibition of Transcriptional CDKs

Small molecule multi-targeted CDK inhibitors (CDKIs) are of particular interest due to their potent antitumor activity independent of p53 gene alterations. P53 deletion is associated with a very poor prognosis in multiple myeloma (MM). In this regard, we tested the anti-MM activity of RGB-286638, an...

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Bibliografische gegevens
Hoofdauteurs: Cirstea, Diana, Hideshima, Teru, Santo, Loredana, Eda, Homare, Mishima, Yuko, Nemani, Neeharika, Hu, Yiguo, Mimura, Naoya, Cottini, Francesca, Gorgun, Gullu, Ohguchi, Hiroto, Suzuki, Rikio, Loferer, Hannes, Munshi, Nikhil C., Anderson, Kenneth C., Raje, Noopur
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928098/
https://ncbi.nlm.nih.gov/pubmed/23807770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.194
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