Asp44 Stabilizes the Trp41 Gate of the M2 Proton Channel of Influenza A Virus

Channel gating and proton conductance of the influenza A virus M2 channel result from complex pH-dependent interactions involving the pore-lining residues His37, Trp41, and Asp44. Protons diffusing from the outside of the virus protonate His37, which opens the Trp41 gate and allows one or more proto...

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Autores principales: Ma, Chunlong, Fiorin, Giacomo, Carnevale, Vincenzo, Wang, Jun, Lamb, Robert A., Klein, Michael L., Wu, Yibing, Pinto, Lawrence H., DeGrado, William F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927992/
https://ncbi.nlm.nih.gov/pubmed/24139991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.08.029
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