Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease

Heterozygous mutations in GBA1, the gene encoding lysosomal glucocerebrosidase, are the most frequent known genetic risk factor for Parkinson’s disease. Reduced glucocerebrosidase and α-synuclein accumulation are directly related in cell models of Parkinson’s disease. We investigated relationships b...

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Autores principales: Murphy, Karen E., Gysbers, Amanda M., Abbott, Sarah K., Tayebi, Nahid, Kim, Woojin S., Sidransky, Ellen, Cooper, Antony, Garner, Brett, Halliday, Glenda M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927701/
https://ncbi.nlm.nih.gov/pubmed/24477431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awt367
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