Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

Cancer cells rely on aerobic glycolysis to maintain cell growth and proliferation via the Warburg effect. Phosphoglycerate dehydrogenase (PHDGH) catalyzes the first step of the serine biosynthetic pathway downstream of glycolysis, which is a metabolic gatekeeper both for macromolecular biosynthesis...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Chen, Jinyun, Chung, Franklin, Yang, Guizhi, Pu, Minying, Gao, Hui, Jiang, Wei, Yin, Hong, Capka, Vladimir, Kasibhatla, Shailaja, Laffitte, Bryan, Jaeger, Savina, Pagliarini, Raymond, Chen, Yaoyu, Zhou, Wenlai
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2013
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926844/
https://ncbi.nlm.nih.gov/pubmed/24318446
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