Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

Cancer cells rely on aerobic glycolysis to maintain cell growth and proliferation via the Warburg effect. Phosphoglycerate dehydrogenase (PHDGH) catalyzes the first step of the serine biosynthetic pathway downstream of glycolysis, which is a metabolic gatekeeper both for macromolecular biosynthesis...

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Main Authors: Chen, Jinyun, Chung, Franklin, Yang, Guizhi, Pu, Minying, Gao, Hui, Jiang, Wei, Yin, Hong, Capka, Vladimir, Kasibhatla, Shailaja, Laffitte, Bryan, Jaeger, Savina, Pagliarini, Raymond, Chen, Yaoyu, Zhou, Wenlai
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2013
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926844/
https://ncbi.nlm.nih.gov/pubmed/24318446
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