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Transporter targeted gatifloxacin prodrugs: Synthesis, permeability, and topical ocular delivery
PURPOSE: To design and synthesize prodrugs of gatifloxacin targeting OCT, MCT, and ATB (0, +) transporters and to identify a prodrug with enhanced delivery to the back of the eye. METHOD: Dimethylamino-propyl, carboxy-propyl, and amino-propyl(2-methyl) derivatives of gatifloxacin (GFX), DMAP-GFX, CP...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3926802/ https://ncbi.nlm.nih.gov/pubmed/23003105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300245r |
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