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Hydrophilic Prodrug Approach for Reduced Pigment Binding and Enhanced Transscleral Retinal Delivery of Celecoxib

PURPOSE: Transscleral retinal delivery of celecoxib, an anti-inflammatory and anti-VEGF agent is restricted by its poor solubility and binding to the melanin pigment in choroid-RPE. The purpose of this study was to develop soluble prodrugs of celecoxib with reduced pigment binding and enhanced retin...

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Detalhes bibliográficos
Main Authors: Malik, Pradip, Kadam, Rajendra S., Cheruvu, Narayan P.S., Kompella, Uday B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311925/
https://ncbi.nlm.nih.gov/pubmed/22256989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp2005164
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