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Hydrophilic Prodrug Approach for Reduced Pigment Binding and Enhanced Transscleral Retinal Delivery of Celecoxib
PURPOSE: Transscleral retinal delivery of celecoxib, an anti-inflammatory and anti-VEGF agent is restricted by its poor solubility and binding to the melanin pigment in choroid-RPE. The purpose of this study was to develop soluble prodrugs of celecoxib with reduced pigment binding and enhanced retin...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3311925/ https://ncbi.nlm.nih.gov/pubmed/22256989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp2005164 |
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