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Influence of Drug Solubility and Lipophilicity on Transscleral Retinal Delivery of Six Corticosteroids

The influence of drug properties including solubility, lipophilicity, tissue partition coefficients, and in vitro transscleral permeability on ex vivo and in vivo transscleral delivery from corticosteroid suspensions was determined. Solubility, tissue/buffer partition coefficients for bovine sclera...

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Main Authors: Thakur, Ashish, Kadam, Rajendra S., Kompella, Uday B.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082374/
https://ncbi.nlm.nih.gov/pubmed/21346004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.037408
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