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Senescent fibroblasts in melanoma initiation and progression: an integrated theoretical, experimental, and clinical approach

We present an integrated study to understand the key role of senescent fibroblasts in driving melanoma progression. Based on the hybrid cellular automata paradigm we developed an in silico model of normal skin. The model focuses on key cellular and microenvironmental variables that regulate interact...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kim, Eunjung, Rebecca, Vito, Fedorenko, Inna V., Messina, Jane L., Mathew, Rahel, Maria-Engler, Silvya S., Basanta, David, Smalley, Keiran S.M., Anderson, Alexander R.A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926439/
https://ncbi.nlm.nih.gov/pubmed/24080279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1720
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