Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues

The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial agonists as pharmacological tools, we have modified 12-epi-sa...

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Main Authors: Béguin, Cécile, Potuzak, Justin, Xu, Wei, Liu-Chen, Lee-Yuan, Streicher, John M., Groer, Chad E., Bohn, Laura M., Carlezon, William A., Cohen, Bruce M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926198/
https://ncbi.nlm.nih.gov/pubmed/22204910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.11.128
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