Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

Antiretroviral therapy can reduce HIV-1 to undetectable levels in peripheral blood, but the effectiveness of treatment in suppressing replication in lymphoid tissue reservoirs has not been determined. Here we show in lymph node samples obtained before and during 6 mo of treatment that the tissue con...

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Main Authors: Fletcher, Courtney V., Staskus, Kathryn, Wietgrefe, Stephen W., Rothenberger, Meghan, Reilly, Cavan, Chipman, Jeffrey G., Beilman, Greg J., Khoruts, Alexander, Thorkelson, Ann, Schmidt, Thomas E., Anderson, Jodi, Perkey, Katherine, Stevenson, Mario, Perelson, Alan S., Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926074/
https://ncbi.nlm.nih.gov/pubmed/24469825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318249111
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