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Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

Antiretroviral therapy can reduce HIV-1 to undetectable levels in peripheral blood, but the effectiveness of treatment in suppressing replication in lymphoid tissue reservoirs has not been determined. Here we show in lymph node samples obtained before and during 6 mo of treatment that the tissue con...

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Bibliografski detalji
Glavni autori: Fletcher, Courtney V., Staskus, Kathryn, Wietgrefe, Stephen W., Rothenberger, Meghan, Reilly, Cavan, Chipman, Jeffrey G., Beilman, Greg J., Khoruts, Alexander, Thorkelson, Ann, Schmidt, Thomas E., Anderson, Jodi, Perkey, Katherine, Stevenson, Mario, Perelson, Alan S., Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926074/
https://ncbi.nlm.nih.gov/pubmed/24469825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318249111
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