Tumor-specific IL-9–producing CD8(+) Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers

Because cytokine-priming signals direct CD8(+) T cells to acquire unique profiles that affect their ability to mediate specific immune responses, here we generated IL-9–skewed CD8(+) T (Tc9) cells by priming with Th9-polarized condition. Compared with type-I CD8(+) cytotoxic T (Tc1) cells, Tc9 secre...

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Hlavní autoři: Lu, Yong, Hong, Bangxing, Li, Haiyan, Zheng, Yuhuan, Zhang, Mingjun, Wang, Siqing, Qian, Jianfei, Yi, Qing
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926063/
https://ncbi.nlm.nih.gov/pubmed/24469818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317431111
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