p38 MAPK-inhibited dendritic cells induce superior antitumor immune responses and overcome regulatory T cell-mediated immunosuppression

Dendritic cell (DC)-based cancer immunotherapy is a promising method but so far has demonstrated limited clinical benefits. Regulatory T cells (Treg) represent a major obstacle to cancer immunotherapy approaches. Here we show that inhibiting p38 MAPK during DC differentiation enables DCs to activate...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lu, Yong, Zhang, Mingjun, Wang, Siqing, Hong, Bangxing, Wang, Zhiqiang, Li, Haiyan, Zheng, Yuhuan, Yang, Jing, Davis, Richard E., Qian, Jianfei, Hou, Jian, Yi, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249595/
https://ncbi.nlm.nih.gov/pubmed/24957461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5229
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