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Two separate defects, affecting true naïve (TNa) or virtual memory (VM) T cell precursors, combine to reduce naïve T cell responses with aging
Naïve T cell responses are eroded with aging. We and others have recently shown that unimmunized old mice lose ≥70% of Ag-specific CD8 T cell precursors and that many of the remaining precursors acquire a “virtual (central) memory” (VM; CD44(hi)CD62L(hi)) phenotype. Here, we demonstrate that unimmun...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3925780/ https://ncbi.nlm.nih.gov/pubmed/24293630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301453 |
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