Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18

In response to infection with intracellular microorganisms, old mice mobilize decreased numbers of antigen-specific CD8 T cells with reduced expression of effector molecules and impaired cytolytic activity. Molecular mechanisms behind these defects and the cell-intrinsic (affecting naïve CD8 T cells...

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Vydáno v:Front Immunol
Hlavní autoři: Jergović, Mladen, Thompson, Heather L., Renkema, Kristin R., Smithey, Megan J., Nikolich-Žugich, Janko
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759569/
https://ncbi.nlm.nih.gov/pubmed/31620129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02206
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