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Brd4 and HEXIM1: Multiple Roles in P-TEFb Regulation and Cancer

Bromodomain-containing protein 4 (Brd4) and hexamethylene bisacetamide (HMBA) inducible protein 1 (HEXIM1) are two opposing regulators of the positive transcription elongation factor b (P-TEFb), which is the master modulator of RNA polymerase II during transcriptional elongation. While Brd4 recruits...

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Autors principals: Chen, Ruichuan, Yik, Jasper H. N., Lew, Qiao Jing, Chao, Sheng-Hao
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925632/
https://ncbi.nlm.nih.gov/pubmed/24592384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/232870
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