Apolipoprotein CIII hyperactivates β cell Ca(V)1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src

Apolipoprotein CIII (ApoCIII) not only serves as an inhibitor of triglyceride hydrolysis but also participates in diabetes-related pathological events such as hyperactivation of voltage-gated Ca(2+) (Ca(V)) channels in the pancreatic β cell. However, nothing is known about the molecular mechanisms w...

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Main Authors: Shi, Yue, Yang, Guang, Yu, Jia, Yu, Lina, Westenbroek, Ruth, Catterall, William A., Juntti-Berggren, Lisa, Berggren, Per-Olof, Yang, Shao-Nian
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Basel 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925466/
https://ncbi.nlm.nih.gov/pubmed/23949443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-013-1442-x
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