Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice

An interstitial deletion of chromosome 5, del(5q), is the most common structural abnormality in primary myelodysplastic syndromes (MDS) and therapy-related myeloid neoplasms (t-MNs) after cytotoxic therapy. Loss of TP53 activity, through mutation or deletion, is highly associated with t-MNs with a d...

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Bibliografiska uppgifter
Huvudupphovsmän: Stoddart, Angela, Fernald, Anthony A., Wang, Jianghong, Davis, Elizabeth M., Karrison, Theodore, Anastasi, John, Le Beau, Michelle M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2014
Ämnen:
Myeloid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924928/
https://ncbi.nlm.nih.gov/pubmed/24381225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-07-517953
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