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Mouse embryonic stem cells undergo Charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment

Embryonic stem cells (ESCs) are hypersensitive to many DNA damaging agents and can rapidly undergo cell death or cell differentiation following exposure. Treatment of mouse ESCs (mESCs) with etoposide (ETO), a topoisomerase II poison, followed by a recovery period resulted in massive cell death with...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Tichy, Elisia D., Stephan, Zachary A., Osterburg, Andrew, Noel, Greg, Stambrook, Peter J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924754/
https://ncbi.nlm.nih.gov/pubmed/23500643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2013.01.010
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