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Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition

EndoG is a ubiquitous nuclease that is translocated into the nucleus during apoptosis to participate in DNA degradation. The enzyme cleaves double- and single-stranded DNA and RNA. Related nucleases are found in eukaryotes and prokaryotes, which have evolved sophisticated mechanisms for genome prote...

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Bibliographic Details
Main Authors: Loll, Bernhard, Gebhardt, Maike, Wahle, Elmar, Meinhart, Anton
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790893/
https://ncbi.nlm.nih.gov/pubmed/19783821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp770
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