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Mouse embryonic stem cells undergo Charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment

Embryonic stem cells (ESCs) are hypersensitive to many DNA damaging agents and can rapidly undergo cell death or cell differentiation following exposure. Treatment of mouse ESCs (mESCs) with etoposide (ETO), a topoisomerase II poison, followed by a recovery period resulted in massive cell death with...

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Detaylı Bibliyografya
Asıl Yazarlar: Tichy, Elisia D., Stephan, Zachary A., Osterburg, Andrew, Noel, Greg, Stambrook, Peter J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924754/
https://ncbi.nlm.nih.gov/pubmed/23500643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2013.01.010
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