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Probabilistic alignment leads to improved accuracy and read coverage for bisulfite sequencing data
BACKGROUND: DNA methylation has been linked to many important biological phenomena. Researchers have recently begun to sequence bisulfite treated DNA to determine its pattern of methylation. However, sequencing reads from bisulfite-converted DNA can vary significantly from the reference genome becau...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BioMed Central
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3924334/ https://ncbi.nlm.nih.gov/pubmed/24261665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-14-337 |
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