Probabilistic alignment leads to improved accuracy and read coverage for bisulfite sequencing data

BACKGROUND: DNA methylation has been linked to many important biological phenomena. Researchers have recently begun to sequence bisulfite treated DNA to determine its pattern of methylation. However, sequencing reads from bisulfite-converted DNA can vary significantly from the reference genome becau...

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Detalhes bibliográficos
Main Authors: Hong, Changjin, Clement, Nathan L, Clement, Spencer, Hammoud, Saher Sue, Carrell, Douglas T, Cairns, Bradley R, Snell, Quinn, Clement, Mark J, Johnson, William Evan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924334/
https://ncbi.nlm.nih.gov/pubmed/24261665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-14-337
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