Control of Foxo1 Gene Expression by Co-activator P300

FOXO1 is an important downstream mediator of the insulin signaling pathway. In the fed state, elevated insulin phosphorylates FOXO1 via AKT, leading to its nuclear exclusion and degradation. A reduction in nuclear FOXO1 levels then leads to suppression of hepatic glucose production. However, the mec...

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Bibliografiset tiedot
Päätekijät: Wondisford, Anne R., Xiong, Lishou, Chang, Evan, Meng, Shumei, Meyers, David J., Li, Mingsong, Cole, Philip A., He, Ling
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2014
Aiheet:
Gene Regulation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924295/
https://ncbi.nlm.nih.gov/pubmed/24379407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.540500
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