Transcriptional Co-activator p300 Maintains Basal Hepatic Gluconeogenesis

A major cause of fasting hyperglycemia in diabetes mellitus is unregulated hepatic glucose production (HGP). Insulin suppresses HGP by phosphorylating CBP and disassembling the CREB-CBP complex from gluconeogenic genes. p300 is closely related to CBP; but in contrast to CBP, p300 binds constitutivel...

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Detalhes bibliográficos
Main Authors: He, Ling, Naik, Karuna, Meng, Shumei, Cao, Jia, Sidhaye, Aniket R., Ma, Anlin, Radovick, Sally, Wondisford, Fredric E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442537/
https://ncbi.nlm.nih.gov/pubmed/22815486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.385864
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