Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)

Metformin is a first-line antidiabetic agent taken by 150 million people across the world every year, yet its mechanism remains only partially understood and controversial. It was proposed that suppression of glucose production in hepatocytes by metformin is AMPK-independent; however, unachievably h...

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Main Authors: Cao, Jia, Meng, Shumei, Chang, Evan, Beckwith-Fickas, Katherine, Xiong, Lishou, Cole, Robert N., Radovick, Sally, Wondisford, Fredric E., He, Ling
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2014
主題:
Gene Regulation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110255/
https://ncbi.nlm.nih.gov/pubmed/24928508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.567271
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