The CUL7/F-box and WD Repeat Domain Containing 8 (CUL7/Fbxw8) Ubiquitin Ligase Promotes Degradation of Hematopoietic Progenitor Kinase 1

HPK1, a member of mammalian Ste20-like serine/threonine kinases, is lost in >95% pancreatic cancer through proteasome-mediated degradation. However, the mechanism of HPK1 loss has not been defined. The aims of this study are to identify the ubiquitin ligase and to examine the mechanisms that targ...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wang, Hua, Chen, Yue, Lin, Ping, Li, Lei, Zhou, Guisheng, Liu, Guangchao, Logsdon, Craig, Jin, Jianping, Abbruzzese, James L., Tan, Tse-Hua, Wang, Huamin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924268/
https://ncbi.nlm.nih.gov/pubmed/24362026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520106
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados