The CUL7/F-box and WD Repeat Domain Containing 8 (CUL7/Fbxw8) Ubiquitin Ligase Promotes Degradation of Hematopoietic Progenitor Kinase 1

HPK1, a member of mammalian Ste20-like serine/threonine kinases, is lost in >95% pancreatic cancer through proteasome-mediated degradation. However, the mechanism of HPK1 loss has not been defined. The aims of this study are to identify the ubiquitin ligase and to examine the mechanisms that targ...

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Bibliografiske detaljer
Main Authors: Wang, Hua, Chen, Yue, Lin, Ping, Li, Lei, Zhou, Guisheng, Liu, Guangchao, Logsdon, Craig, Jin, Jianping, Abbruzzese, James L., Tan, Tse-Hua, Wang, Huamin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924268/
https://ncbi.nlm.nih.gov/pubmed/24362026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520106
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