Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice

BACKGROUND: Currently used mouse models fail to fully reflect human immunity to tuberculosis (TB), which hampers progress in research and vaccine development. Bone marrow-liver-thymus (BLT) mice, generated by engrafting human fetal liver, thymus, and hematopoietic stem cells in severely immunodefici...

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Bibliographic Details
Main Authors: Lee, Jinhee, Brehm, Michael A, Greiner, Dale, Shultz, Leonard D, Kornfeld, Hardy
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924189/
https://ncbi.nlm.nih.gov/pubmed/24313934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-14-53
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