Identification of the principal aflatoxin B1-DNA adduct formed in vivo in rat liver.

The products of in vivo covalent binding of activated aflatoxin B1 (AFB1) to DNA have been investigated in rats. The principal covalent product formed in liver DNA of rats treated with AFB1 has been identified as 2,3-dihydro-2-(N7-guanyl)-3-hydroxy-aflatoxin B1. This compound was isolated from the l...

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הוצא לאור ב:	Proc Natl Acad Sci U S A
Principais autores:	Croy, R G, Essigmann, J M, Reinhold, V N, Wogan, G N
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 1978
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/273905/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.4.1745
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