Identification of the principal aflatoxin B1-DNA adduct formed in vivo in rat liver.

The products of in vivo covalent binding of activated aflatoxin B1 (AFB1) to DNA have been investigated in rats. The principal covalent product formed in liver DNA of rats treated with AFB1 has been identified as 2,3-dihydro-2-(N7-guanyl)-3-hydroxy-aflatoxin B1. This compound was isolated from the l...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Croy, R G, Essigmann, J M, Reinhold, V N, Wogan, G N
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1978
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/273905/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.4.1745
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