Sterigmatocystin-DNA interactions: identification of a major adduct formed after metabolic activation in vitro.

Sterigmatocystin (ST), a potent hepatocarcinogen, was covalently bound to calf thymus DNA by incubation in the presence of phenobarbital-induced rat liver microsomes. Acid hydrolysis of ST-modified DNA liberated a major guanine-containing adduct, present in DNA at an estimated level of 1 ST residue...

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Detalhes bibliográficos
Main Authors: Essigmann, J M, Barker, L J, Fowler, K W, Francisco, M A, Reinhold, V N, Wogan, G N
Formato: Artigo
Idioma:Inglês
Publicado em: 1979
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC382900/
https://ncbi.nlm.nih.gov/pubmed/284330
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