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Sterigmatocystin-DNA interactions: identification of a major adduct formed after metabolic activation in vitro.

Sterigmatocystin (ST), a potent hepatocarcinogen, was covalently bound to calf thymus DNA by incubation in the presence of phenobarbital-induced rat liver microsomes. Acid hydrolysis of ST-modified DNA liberated a major guanine-containing adduct, present in DNA at an estimated level of 1 ST residue...

Ausführliche Beschreibung

Gespeichert in:
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Essigmann, J M, Barker, L J, Fowler, K W, Francisco, M A, Reinhold, V N, Wogan, G N
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1979
Schlagworte:
Research Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC382900/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/284330/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.1.179
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