Computational Studies on Sirtuins from Trypanosoma cruzi: Structures, Conformations and Interactions with Phytochemicals

BACKGROUND: The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T. cruzi, the protozoan responsible for Chagas...

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Detalhes bibliográficos
Main Authors: Sacconnay, Lionel, Angleviel, Melissa, Randazzo, Giuseppe Marco, Marçal Ferreira Queiroz, Marcos, Ferreira Queiroz, Emerson, Wolfender, Jean-Luc, Carrupt, Pierre-Alain, Nurisso, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923677/
https://ncbi.nlm.nih.gov/pubmed/24551254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002689
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