Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease

Acetylation of lysine is a major posttranslational modification of proteins and is catalyzed by lysine acetyltransferases, while lysine deacetylases remove acetyl groups. Among the deacetylases, the sirtuins are NAD(+)-dependent enzymes, which modulate gene silencing, DNA damage repair, and several...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Moretti, Nilmar Silvio, da Silva Augusto, Leonardo, Clemente, Tatiana Mordente, Antunes, Raysa Paes Pinto, Yoshida, Nobuko, Torrecilhas, Ana Claudia, Cano, Maria Isabel Nogueira, Schenkman, Sergio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505258/
https://ncbi.nlm.nih.gov/pubmed/26014945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04694-14
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